Nrf2 signaling and cell survival
نویسندگان
چکیده
منابع مشابه
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependent antioxidant signaling by physically interacting with Nrf2 and promoting its stability and activ...
متن کاملSoluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregat...
متن کاملERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells.
The ERK and PI3K signaling cascades are aberrantly activated in human glioblastoma cells, resulting in the dysregulation of numerous downstream transcription factors. The dark side of the transcription factor, NF-E2-related factor 2 (Nrf2) in human cancer has been revealed. It has been accepted that high levels of Nrf2 promote tumor progression. In the present study, we investigated the effect ...
متن کاملp62 links autophagy and Nrf2 signaling.
The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis that functions to protect cells against oxidative stress, environmental toxicants, and harmful chemicals through the induction of cytoprotective genes. To enforce strict regulation, cells invest a great deal of energy into the maintenance of the Nrf2 pathway to ensure rapid induction upon cellular insult and rapid ret...
متن کاملEffect of Resistance and Endurance Trainings on Nrf2/Keap1 Signaling Pathway in Testicular Tissue of Type 2 Diabetic Rats
Background and purpose: The antioxidant Nrf2/Keap1 pathway prevents cellular damages against oxidative stress and this pathway is disrupted following diabetes. The aim of this study was to investigate the effect of endurance and resistance training on antioxidant Nrf2/Keap1 pathway in testicular tissue of diabetic rats. Materials and methods: In this experimental research, 48 male Wistar rats ...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2010
ISSN: 0041-008X
DOI: 10.1016/j.taap.2009.06.009